kodon consult

Publications

  • “Combinatorial Biosynthesis of Polyketides”; K. Donsbach, K. Rück-Braun in “Organic Synthesis Highlights IV”; Ed. H. G. Schmalz, VCH 2000, 343-350
  • “First Scale-Up to Production Scale of a Ring Closing Metathesis Reaction Forming a 15-Membered Macrocycle as a Precursor of an Active Pharmaceutical Ingredient”; T. Nicola, M. Brenner, K. Donsbach, and P. Kreye; Org. Process Res. Dev.; 2005; 9, 513-515
  • “Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring- Closing Metathesis”; Yee, N. K.; Farina, V.; Houpis, I. N.; Haddad, N.; Frutos, R. P.; Gallou, F.; Wang, X.-j.; Wei, X.; Simpson, R. D.; Feng, X.; Fuchs, V.; Xu, Y.; Tan, J.; Zhang, L.; Xu, J.; Smith-Keenan, L. L.; Vitous, J.; Ridges, M. D.; Spinelli, E. M.; Johnson, M.; Donsbach, K.; Nicola, T.; Brenner, M.; Winter, E.; Kreye, P.; Samstag, W.; J. Org. Chem., 2006; 71, 7133-7145
  • “Synthesis of BILN 2061”, N.K. Yee, V. Farina, K. Donsbach, Synfacts, 2007
  • “Chemoenzymatic Synthesis of a Chiral Ozanimod Key Intermediate Starting from Naphthalene as Cheap Petrochemical Feedstock”; Uthoff, F.; Harms, C.; Löwe, J.; Donsbach, K.; Gröger, H.; J. Org. Chem., 2019; 84, 8, 4856-4866
  • “Functional Expression and Characterization of a Panel of Cobalt and Iron-Dependent Nitrile Hydratases”; Grill, B.; Glänzer, M.; Schwab, H.; Steiner, K.; Pienaar, D.; Brady, D. Donsbach, K.; Winkler, M.; Molecules, 2020, 25(11):2521
  • „Gordonia hydrophobica Nitrile Hydratase for Amide Preparation from Nitriles”; Birgit Grill ,Melissa Horvat, Helmut Schwab, Ralf Gross, Kai Donsbach, and Margit Winkler; Catalysts 2021, 11(11), 1287
  • “The “Green” Electrochemical Synthesis of Periodate”; Arndt, S.; Weis, D. Donsbach, K.; Waldvogel, S.R.; Angew. Chem. 2020, 132, 1-7  “Knappe Kapazitäten”; K. Donsbach, T. Opatz, M. Psiorz, Nachrichten aus der Chemie, 2021, 68(10), pp.26-29.  “The sustainable synthesis of levetiracetam by an enzymatic dynamic kinetic resolution and an ex-cell anodic oxidation”; Arndt, S.; Grill, B.; Schwab, H.; Steinkellner, G.; Pogorevčnik, U.; Weis, D.; Nauth, A.M.; Gruber, K.; Opatz, T.; Donsbach, K.; Waldvogel, S.R.; Winkler, M.; Green Chem., 2021, 23, 388-395
  • “Synthesis and Applications of Periodate for Fine Chemicals and Important Pharmaceuticals”; S. Arndt, P. J. Kohlpaintner, K. Donsbach, S. R. Waldvogel, Org. Process Res. Dev. 2022, 26, 9, 2564–2613
  • “Efforts to Develop a Cost-Effective and Scalable Synthetic Process for Nirmatrelvir”; C. S. Shanahan, A. L. Kadam, B. Chiranjeevi, A. A. Nunes, A. Jayaraman, S. Ahmad, S. L. Aleshire, K. O. Donsbach, B. F. Gupton, M. C. Nuckols; ChemRxiv. Cambridge: Cambridge Open Engage; 2022
  • “Development of a Practical Synthesis of the 8-FDC Fragment of OPC-167832”; V. Gopalsamuthiram, D. B. Ho, C. L. Peck, V. Natarajan, T. Agrawal, J. M. Burns, J. Bachert, D. W. Cook, R. W. Stringham, R. Nelson, S. Ahmad, B. F. Gupton, D. R. Snead, D. T. McQuade, R. Vaidyanathan, K. Donsbach, J. D. Sieber; ACS Omega 2022 7 (8), 7223-7228
  • “Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline”; J.M.S. Robey, S. Maity, S.L. Aleshire, A. Ghosh, A.K. Yadaw, S. Roy, S.J. Mear, T.F. Jamison, G. Sirasani, C.H. Senanayake, R.W. Stringham, B.F. Gupton, K.O. Donsbach, R.C. Nelson, C.S. Shanahan; Org. Process Res. Dev. 2023, 27, 11, 2146–2159
  • “Short and Efficient Synthesis of the Antituberculosis Agent Pretomanid from (R)-Glycidol”; T. Lucas, J.-P. Dietz, F.S.P. Cardoso, D.R. Snead, R.C. Nelson, K.O. Donsbach, B.F. Gupton, T. Opatz; Org. Process Res. Dev. 2023, 27, 9, 1641-1651
  • “Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223”; F.S.P. Cardoso, A.L. Kadam, R.C. Nelson, J.W. Tomlin, D. Dahal, C.S. Kuehner, G. Gudvangen, A.J. Arduengo III, J.M. Burns, S.L. Aleshire, D.R. Snead, F. Qu, K. Belmore, S. Ahmad, T. Agrawal, J.D. Sieber, and K.O. Donsbach; Org. Process Res. Dev. 2023, 27, 7, 1390-1399
  • “Protecting Group-Free Synthesis of the Antimalaria Drug MMV693183”; Khairnar P, Aleshire S, Ongolu R, Jin Limei, Laidlaw M, Nelson R, Donsbach K, Gupton F, Shanahan C; ChemRxiv. Cambridge: 2023
  • “Scale-Up and Development of a One-Step Process for the Synthesis of Succinylcholine”; Brijesh M. Sharma, Nakul Telang, Daniel W. Cook, Justina M. Burns, Rodger W. Stringham, Kai O. Donsbach, and Tai-Yuen Yue; Org. Process Res. Dev. 2024, 28, 1, 248-257
  • “Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183”; Pankaj V. Khairnar, Sarah L. Aleshire, Ravi Kumar Ongolu, Limei Jin, Michael G. Laidlaw, Kai O. Donsbach, B. Frank Gupton, Ryan C. Nelson, and Charles S. Shanahan*; Org. Process Res. Dev. 2024, 28, 1, 273-280
  • “Synthesis of Chiral 1,2-Amino Alcohol-Containing Compounds Utilizing Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Unprotected α-Ketoamines”; H.P.R. Mangunuru, L. Terrab, V. Janganati, N. R. Kalikinidi, S. Tenneti, V. Natarajan, A.D.R. Shada, S.R. Naini, P. Gajula, D. Lee, L.P. Samankumara, M. Mamunooru, A. Jayaraman, R.L. Sahani, J. Yin, C.C. Hewa-Rahinduwage, A. Gangu, A. Chen, Z. Wang, B. Desai, T.Y. Yue, C.S. Wannere, J.D. Armstrong III, K. O. Donsbach, G, Sirasani, B. F. Gupton, B. Qu, C.H. Senanayake, J. Org. Chem. 2024, 89, 9, 6085–6099
  • “Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148”; P.V. Khairnar, J.M. Saathoff, D.W. Cook, S.R. Hochstetler, U. Pandya, S.J. Robinson, V. Satam, K.O. Donsbach, B.F. Gupton, L.-M. Jin, C. S. Shanahan, Org. Process Res. Dev. 2024, 28, 4, 1213–1223
  • “Expansion of the Green Chemistry Principles: Inclusion of Greenhouse Gases and Carbon Footprint”; K. Rossen, K. Ganesh, K.O. Donsbach, Org. Process Res. Dev. 2024, 28, 3753−3756
  • “Making Anti-Tuberculosis Drug Bedaquiline Affordable by Tackling Low-Yielding Key Steps”; Juliana M. S. Robey, Kai O. Donsbach; DOI: 10.1021/bk-2025-1505.ch007; in: “Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry Volume 5”; Jaan A. Pesti, Ahmed F. Abdel-Magid, Rajappa Vaidyanathan; ACS Symposium SeriesVol. 1505, eISBN: 9780841296947; Chapter 7; pp 281-310